Details

Autor(en) / Beteiligte

• Gaayeb, Lobna
• Sarr, Jean B
• Cames, Cecile
• Pinçon, Claire
• Hanon, Jean-Baptiste
• Ndiath, Mamadou O
• Seck, Modou
• Herbert, Fabien
• Sagna, Andre B
• Schacht, Anne-Marie
• Remoue, Franck
• Riveau, Gilles
• Hermann, Emmanuel

Titel

Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal

Ist Teil von

• The American journal of tropical medicine and hygiene, 2014-03, Vol.90 (3), p.566-573

Ort / Verlag

United States: The American Society of Tropical Medicine and Hygiene

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. A relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time. Moreover, a whole-blood stimulation assay highlighted that the production of interferon-γ (IFN-γ) in response to tetanus toxoid was compromised in stunted children. However, the absence of cytokine modulation in response to Mycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce IFN-γ was preserved in stunted children. Therefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus.