Details

Autor(en) / Beteiligte

• Goffin, Darren
• Ali, Afia B
• Rampersaud, Nazir
• Harkavyi, Alexander
• Fuchs, Celine
• Whitton, Peter S
• Nairn, Angus C
• Jovanovic, Jasmina N

Titel

Dopamine-Dependent Tuning of Striatal Inhibitory Synaptogenesis

Ist Teil von

• The Journal of neuroscience, 2010-02, Vol.30 (8), p.2935-2950

Ort / Verlag

United States: Soc Neuroscience

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Dopaminergic projections to the striatum, crucial for the correct functioning of this brain region in adulthood, are known to be established early in development, but their role is currently uncharacterized. We demonstrate here that dopamine, by activating D(1)- and/or D(2)-dopamine receptors, decreases the number of functional GABAergic synapses formed between the embryonic precursors of the medium spiny neurons, the principal output neurons of the striatum, with associated changes in spontaneous synaptic activity. Activation of these receptors reduces the size of postsynaptic GABA(A) receptor clusters and their overall cell-surface expression, without affecting the total number of clusters or the size or number of GABAergic nerve terminals. These changes result from an increased internalization of GABA(A) receptors, and are mediated by distinct signaling pathways converging at the level of GABA(A) receptors to cause a transient PP2A/PP1-dependent dephosphorylation. Thus, tonic D(1)- and D(2)-receptor activity limits the extent of collateral inhibitory synaptogenesis between medium spiny neurons, revealing a novel role of dopamine in controlling the development of intrinsic striatal microcircuits.