Details

Autor(en) / Beteiligte

• XIANGFENG LU
• LAIYUAN WANG
• TANGCHUN WU
• YITONG MA
• JIANXIN LI
• JIE CAO
• JICHUN CHEN
• DONGLIANG GE
• ZHONGJIE FAN
• YING LI
• LIANCHENG ZHAO
• HONGFAN LI
• SHUFENG CHEN
• XIAOYANG ZHOU
• LANYING CHEN
• DONGHUA LIU
• JINGPING CHEN
• XIUFANG DUAN
• YONGCHEN HAO
• LIGUI WANG
• FANGHONG LU
• ZHENDONG LIU
• CAILIANG YAO
• LIN HE
• CHONG SHEN
• XIAODONG PU
• LIN YU
• XIANGHUA FANG
• LIHUA XU
• JIANJUN MU
• XIANPING WU
• RUNPING ZHENG
• NAQIONG WU
• QI ZHAO
• XUELI YANG
• YUN LI
• XIAOLI LIU
• MENGQIN WANG
• DAHAI YU
• DONGSHENG HU
• XU JI
• DONGSHUANG GUO
• DONGLING SUN
• QIANQIAN WANG
• YING YANG
• YONGYONG SHI
• FANGCHAO LIU
• QUNXIA MAO
• XIAOHUA LIANG
• JINGFENG JI
• PANPAN CHEN
• XINGBO MO
• DIANJIANG LI
• GUOPING CHAI
• YIDA TANG
• XIANGDONG LI
• JING CHENG
• LIANG ZHANG
• GU, C. Charles
• JIANFENG HUANG

Titel

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Ist Teil von

• Nature genetics, 2012-08, Vol.44 (8), p.890-894

Ort / Verlag

New York, NY: Nature Publishing Group

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.