Nature structural & molecular biology, 2007-02, Vol.14 (2), p.169-171
2007
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- Autor(en) / Beteiligte
- Titel
- Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC
- Ist Teil von
- Nature structural & molecular biology, 2007-02, Vol.14 (2), p.169-171
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- 'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-Å resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vβ but with TCR Vα.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1545-9993eISSN: 1545-9985DOI: 10.1038/nsmb1193Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3923521
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animals, Antigen receptors, T cell, Antigens, Bacterial, Cellular biology, Conformation, Crystal structure, Crystallography, X-Ray, Hemagglutinins - chemistry, HLA-DR1 Antigen - chemistry, Humans, Major histocompatibility complex, Mice, Mitogens - chemistry, Models, Molecular, Molecular biology, Molecular Sequence Data, Molecular structure, Mycoplasma arthritidis, Mycoplasma arthritidis - immunology, Peptides, Peptides - chemistry, Physiological aspects, Proteins, Proteins - chemistry, Receptors, Receptors, Antigen, T-Cell, alpha-beta - chemistry, Structure, Superantigens - chemistry, T cells