Details

Autor(en) / Beteiligte

• Yoon, Seung Bae
• Park, Jae Myung
• Lee, Jong-Yul
• Baeg, Myong Ki
• Lim, Chul-Hyun
• Kim, Jin Soo
• Cho, Yu Kyung
• Lee, In Seok
• Kim, Sang Woo
• Choi, Myung-Gyu

Titel

Long-term pretreatment with proton pump inhibitor and Helicobacter pylori eradication rates

Ist Teil von

• World journal of gastroenterology : WJG, 2014-01, Vol.20 (4), p.1061-1066

Ort / Verlag

United States: Baishideng Publishing Group Co., Limited

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• AIM:To investigate whether proton pump inhibitor(PPI)pretreatment influences Helicobacter pylori eradication rate.METHODS:We retrospectively reviewed H.pylori-infected patients who were treated with a standard triple regimen(PPI,amoxicillin 1 g,and clarithromycin 500mg,all twice daily for 7 d).The diagnosis of H.pylori infection and its eradication was assessed with the rapid urease test,histological examination by silver staining,or the13C-urea breath test.We divided the patients into two groups:one received the standard eradication regimen without PPI pretreatment(Group A),and the other received PPI pretreatment(Group B).The patients in Group B were reclassified into three groups based on the duration of PPI pretreatment:Group B-Ⅰ(3-14 d),Group B-Ⅱ(15-55 d),and Group B-Ⅲ(≥56 d).RESULTS:A total of 1090 patients were analyzed and the overall eradication rate was 80.9%.The cure rate in Group B(81.2%,420/517)was not significantly different from that in Group A(79.2%,454/573).The eradication rates in Group B-Ⅰ,B-Ⅱand B-Ⅲwere80.1%(117/146),81.8%(224/274)and 81.4%(79/97),respectively.CONCLUSION:PPI pretreatment did not affect H.pylori eradication rate,regardless of the medication period.