Details

Autor(en) / Beteiligte

• Choo, Siew Woh
• Wee, Wei Yee
• Ngeow, Yun Fong
• Mitchell, Wayne
• Tan, Joon Liang
• Wong, Guat Jah
• Zhao, Yongbing
• Xiao, Jingfa

Titel

Genomic reconnaissance of clinical isolates of emerging human pathogen Mycobacterium abscessus reveals high evolutionary potential

Ist Teil von

• Scientific reports, 2014-02, Vol.4 (1), p.4061-4061, Article 4061

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Mycobacterium abscessus (Ma) is an emerging human pathogen that causes both soft tissue infections and systemic disease. We present the first comparative whole-genome study of Ma strains isolated from patients of wide geographical origin. We found a high proportion of accessory strain-specific genes indicating an open, non-conservative pan-genome structure and clear evidence of rapid phage-mediated evolution. Although we found fewer virulence factors in Ma compared to M. tuberculosis , our data indicated that Ma evolves rapidly and therefore should be monitored closely for the acquisition of more pathogenic traits. This comparative study provides a better understanding of Ma and forms the basis for future functional work on this important pathogen.