Neuroscience, 2013-08, Vol.244, p.16-30
2013
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- Autor(en) / Beteiligte
- Titel
- The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice
- Ist Teil von
- Neuroscience, 2013-08, Vol.244, p.16-30
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Autophagy contributes to brain damage after focal ischemia in the barrel cortex. • The autophagic cell death increases in adult NF-κB p50 knockout mice. • The autophagic damage involves neuronal and vascular cells. • A reduction of Akt-mTOR signaling may contribute to the autophagy activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2013.03.045Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3916093
- Format
- –
- Schlagworte
- Adenine - analogs & derivatives, Adenine - pharmacology, Akt, the mammalian target of rapamycin (mTOR), Animals, autophagy, Autophagy - drug effects, Autophagy - physiology, Biological and medical sciences, Blood-Brain Barrier - physiopathology, blood–brain barrier, Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges, Cerebral Cortex - drug effects, Cerebral Cortex - metabolism, Cerebral Cortex - physiopathology, cerebral ischemia, Fundamental and applied biological sciences. Psychology, Infarction, Middle Cerebral Artery - metabolism, Infarction, Middle Cerebral Artery - physiopathology, Male, Medical sciences, Mice, Mice, Knockout, Neurology, neurovascular unit, NF-kappa B - physiology, NF-kappa B p50 Subunit - genetics, NF-kappaB, Proto-Oncogene Proteins c-akt - metabolism, Signal Transduction, TOR Serine-Threonine Kinases - metabolism, Vascular diseases and vascular malformations of the nervous system, Vertebrates: nervous system and sense organs