Details

Autor(en) / Beteiligte

• Furukawa, Kyoji
• Preston, Dale
• Funamoto, Sachiyo
• Yonehara, Shuji
• Ito, Masahiro
• Tokuoka, Shoji
• Sugiyama, Hiromi
• Soda, Midori
• Ozasa, Kotaro
• Mabuchi, Kiyohiko

Titel

Long‐term trend of thyroid cancer risk among Japanese atomic‐bomb survivors: 60 years after exposure

Ist Teil von

• International journal of cancer, 2013-03, Vol.132 (5), p.1222-1226

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2013

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Thyroid cancer risk following exposure to ionizing radiation in childhood and adolescence is a topic of public concern. To characterize the long‐term temporal trend and age‐at‐exposure variation in the radiation‐induced risk of thyroid cancer, we analyzed thyroid cancer incidence data for the period from 1958 through 2005 among 105,401 members of the Life Span Study cohort of Japanese atomic‐bomb survivors. During the follow‐up period, 371 thyroid cancer cases (excluding those with microcarcinoma with a diameter <10 mm) were identified as a first primary among the eligible subjects. Using a linear dose–response model, the excess relative risk of thyroid cancer at 1 Gy of radiation exposure was estimated as 1.28 (95% confidence interval: 0.59–2.70) at age 60 after acute exposure at age 10. The risk decreased sharply with increasing age‐at‐exposure and there was little evidence of increased thyroid cancer rates for those exposed after age 20. About 36% of the thyroid cancer cases among those exposed before age 20 were estimated to be attributable to radiation exposure. While the magnitude of the excess risk has decreased with increasing attained age or time since exposure, the excess thyroid cancer risk associated with childhood exposure has persisted for >50 years after exposure. What's new? Japanese atomic‐bomb survivors have been a critical source of information for insight into radiation‐related thyroid cancer risk. In this analysis of survivor data from 1958 through 2005—one of the longest follow‐up studies on thyroid cancer to date—radiation‐associated thyroid cancer risk was found to persist for more than 50 years. The continued increase in risk, which was associated with long life and exposure to radiation in childhood or adolescence, could have important implications for clinical practice and public health measures.