Details

Autor(en) / Beteiligte

• Li, Wenlin
• Li, Ke
• Wei, Wanguo
• Ding, Sheng

Titel

Chemical Approaches to Stem Cell Biology and Therapeutics

Ist Teil von

• Cell stem cell, 2013-09, Vol.13 (3), p.270-283

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine. This Review discusses recent progress in using chemical approaches to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and considers future challenges for applications in regenerative medicine.