Details

Autor(en) / Beteiligte

• Kleinridders, André
• Schenten, Dominik
• Könner, A. Christine
• Belgardt, Bengt F.
• Mauer, Jan
• Okamura, Tomoo
• Wunderlich, F. Thomas
• Medzhitov, Ruslan
• Brüning, Jens C.

Titel

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

Ist Teil von

• Cell metabolism, 2009-10, Vol.10 (4), p.249-259

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2009

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Obesity-associated activation of inflammatory pathways represents a key step in the development of insulin resistance in peripheral organs, partially via activation of TLR4 signaling by fatty acids. Here, we demonstrate that palmitate acting in the central nervous system (CNS) inhibits leptin-induced anorexia and Stat3 activation. To determine the functional significance of TLR signaling in the CNS in the development of leptin resistance and diet-induced obesity in vivo, we have characterized mice deficient for the TLR adaptor molecule MyD88 in the CNS (MyD88 ΔCNS). Compared to control mice, MyD88 ΔCNS mice are protected from high-fat diet (HFD)-induced weight gain, from the development of HFD-induced leptin resistance, and from the induction of leptin resistance by acute central application of palmitate. Moreover, CNS-restricted MyD88 deletion protects from HFD- and icv palmitate-induced impairment of peripheral glucose metabolism. Thus, we define neuronal MyD88-dependent signaling as a key regulator of diet-induced leptin and insulin resistance in vivo.