Details

Autor(en) / Beteiligte

• Licona-Limón, Paula
• Henao-Mejia, Jorge
• Temann, Angela U.
• Gagliani, Nicola
• Licona-Limón, Ileana
• Ishigame, Harumichi
• Hao, Liming
• Herbert, De’Broski R.
• Flavell, Richard A.

Titel

Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection

Ist Teil von

• Immunity (Cambridge, Mass.), 2013-10, Vol.39 (4), p.744-757

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Type 2 inflammatory cytokines, including interleukin-4 (IL-4), IL-5, IL-9, and IL-13, drive the characteristic features of immunity against parasitic worms and allergens. Whether IL-9 serves an essential role in the initiation of host-protective responses is controversial, and the importance of IL-9- versus IL-4-producing CD4+ effector T cells in type 2 immunity is incompletely defined. Herein, we generated IL-9-deficient and IL-9-fluorescent reporter mice that demonstrated an essential role for this cytokine in the early type 2 immunity against Nippostrongylus brasiliensis. Whereas T helper 9 (Th9) cells and type 2 innate lymphoid cells (ILC2s) were major sources of infection-induced IL-9 production, the adoptive transfer of Th9 cells, but not Th2 cells, caused rapid worm expulsion, marked basophilia, and increased mast cell numbers in Rag2-deficient hosts. Taken together, our data show a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection. •IL-9 is expressed early upon hookworm infection•IL-9 works as a nonredundant type 2 cytokine during helminth infection•Th9 cells and ILC2s are the natural sources of IL-9 in vivo•Th9 cells represent a specialized Th cell subset driving anti-helminth immunity