Details

Autor(en) / Beteiligte

• Śladowska, Anna
• Hetnał, Marcin
• Dymek, Paweł
• Kabat, Damian
• Kisielewicz, Kamil
• Wawrzak, Michał
• Zawadzki, Paweł
• Lesiak, Jan
• Byrski, Edward
• Waligórski, Michał

Titel

Application of IMRT in adjuvant treatment of soft tissue sarcomas of the thigh—Preliminary results

Ist Teil von

• Reports of practical oncology and radiotherapy, 2011, Vol.16 (3), p.110-114

Ort / Verlag

Netherlands: Elsevier Urban & Partner (Poland)

Erscheinungsjahr

2011

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Abstract Background Fracture of the femur is the most frequent late complication in patients with soft tissue sarcomas (STS) who receive external beam radiotherapy after limb-sparing surgery. Aim To reduce the risk of bone fracture following radiotherapy of STS of the thigh, we minimized the dose to the femur and to surrounding normal tissues by applying intensity modulated radiation therapy (IMRT). We report preliminary results of post-surgery IMRT of the thigh in patients with STS in this extremity. Materials and methods 10 adult patients undergoing post-operative radiotherapy of STS of the thigh were treated using IMRT. Clinical IMRT plans with simultaneous integrated boost (SIB) and 3-phase three-dimensional conformal radiotherapy (3D-CRT) were designed to adequately treat the planning target volume and to spare the femur to the largest extent possible. Dose distributions and dose-volume histograms were compared. Results For either technique, a comparable target coverage was achieved; however, target volume was better covered and critical structures were better spared in IMRT plans. Mean and maximum doses to OAR structures were also significantly reduced in the IMRT plans. On average, the mean dose to the femur in 3D-CRT plans was about two times higher than that in IMRT plans. Conclusion Compared with 3D-CRT, the application of IMRT improves the dose distribution within the concave target volumes and reduces dose to the OAR structures without compromising target coverage.