Molecular psychiatry, 2014-07, Vol.19 (7), p.848-852
2014
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- Autor(en) / Beteiligte
- Titel
- Identification of differentially expressed microRNAs across the developing human brain
- Ist Teil von
- Molecular psychiatry, 2014-07, Vol.19 (7), p.848-852
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We present a spatio-temporal assessment of microRNA (miRNA) expression throughout early human brain development. We assessed the prefrontal cortex, hippocampus and cerebellum of 18 normal human donor brains spanning infancy through adolescence by RNA-seq. We discovered differentially expressed miRNAs and broad miRNA patterns across both temporal and spatial dimensions, and between male and female prefrontal cortex. Putative target genes of the differentially expressed miRNAs were identified, which demonstrated functional enrichment for transcription regulation, synaptogenesis and other basic intracellular processes. Sex-biased miRNAs also targeted genes related to Wnt and transforming growth factor-beta pathways. The differentially expressed miRNA targets were highly enriched for gene sets related to autism, schizophrenia, bipolar disorder and depression, but not neurodegenerative diseases, epilepsy or other adult-onset psychiatric diseases. Our results suggest critical roles for the identified miRNAs in transcriptional networks of the developing human brain and neurodevelopmental disorders.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1359-4184eISSN: 1476-5578DOI: 10.1038/mp.2013.93Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3840150
- Format
- –
- Schlagworte
- Adolescent, Algorithms, Autism, Biological and medical sciences, Bipolar disorder, Brain, Brain - growth & development, Brain - metabolism, Cerebellum, Cerebellum - metabolism, Child, Child development, Child, Preschool, Childrens health, Cortex (temporal), Developmental neurology, Disease, Epilepsy, Female, Females, Gender differences, Gene expression, Gene Expression Regulation, Developmental - genetics, Gene regulation, Hippocampus - metabolism, Humans, Infant, Male, Medical sciences, Mental disorders, Mental Disorders - genetics, MicroRNA, MicroRNAs, MicroRNAs - analysis, MicroRNAs - biosynthesis, MicroRNAs - genetics, miRNA, Neurodegenerative diseases, Neurodegenerative Diseases - genetics, Neurodevelopmental disorders, Ontology, Physiological aspects, Prefrontal cortex, Prefrontal Cortex - metabolism, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Schizophrenia, Sex Characteristics, Synaptogenesis, Transcription, Transforming growth factor-b, Wnt protein, Young Adult