Details

Autor(en) / Beteiligte

• Hatamian, Hamidreza
• Bidabadi, Elham
• Seyed Saadat, Seyed Mohammad
• Saadat, Niloufar Seyed
• Kazemnezhad, Ehsan
• Ramezani, Hamed
• Bakhshayesh, Babak

Titel

Is serum vitamin D levels associated with disability in patients with newly diagnosed multiple sclerosis?

Ist Teil von

• Iranian journal of neurology, 2013, Vol.12 (2), p.41-46

Ort / Verlag

Iran: Tehran University of Medical Sciences

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Although the precise etiology of multiple sclerosis (MS) is unknown, it seems that both genetic and environmental factors are important. Recent studies suggest that low serum vitamin D levels are important environmental factor in MS. The aim of this study was to compare the serum levels of vitamin D between MS patients and healthy subjects, and to determine its association with disability in MS patients. In this cross-sectional study, a total of 52 patients with MS were randomly recruited and matched for age and sex with 52 healthy subjects. Demographic characteristics and serum vitamin D levels for both groups, as well as duration of disease Expanded Disability Status Scale (EDSS) for MS patients were evaluated. Statistical analysis was performed by independent samples t-test and multiple linear regression analysis. The mean serum vitamin D levels were 26.5 ± 16.3 ng/ml in MS patients vs. 37.1 ±19.7 in healthy subjects (P = 0.003). A linear regression analysis showed no significant association between vitamin D levels and EDSS score of patients with MS (P = 0.345), after adjusting for the covariates. Our findings did not suggest a protective association for serum vitamin D levels against disability in MS patients.