Immunity (Cambridge, Mass.), 2012-07, Vol.37 (1), p.74-84
2012
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- Autor(en) / Beteiligte
- Titel
- The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury
- Ist Teil von
- Immunity (Cambridge, Mass.), 2012-07, Vol.37 (1), p.74-84
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2012
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Epithelial keratinocyte proliferation is an essential element of wound repair, and abnormal epithelial proliferation is an intrinsic element in the skin disorder psoriasis. The factors that trigger epithelial proliferation in these inflammatory processes are incompletely understood. Here we have shown that regenerating islet-derived protein 3-alpha (REG3A) is highly expressed in keratinocytes during psoriasis and wound repair and in imiquimod-induced psoriatic skin lesions. The expression of REG3A by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA) and feeds back on keratinocytes to inhibit terminal differentiation and increase cell proliferation by binding to exostosin-like 3 (EXTL3) followed by activation of phosphatidylinositol 3 kinase (PI3K) and the kinase AKT. These findings reveal that REG3A, a secreted intestinal antimicrobial protein, can promote skin keratinocyte proliferation and can be induced by IL-17. This observation suggests that REG3A may mediate the epidermal hyperproliferation observed in normal wound repair and in psoriasis. [Display omitted] ► REG3A is abundantly expressed in psoriasis and skin wounds ► IL-17 induces REG3A in epidermal keratinocytes ► REG3A induces keratinocyte proliferation but inhibits its differentiation ► REG3A activates EXTL3-PI3K-Akt to promote wound healing
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1074-7613eISSN: 1097-4180DOI: 10.1016/j.immuni.2012.04.010Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3828049
- Format
- –
- Schlagworte
- 1-Phosphatidylinositol 3-kinase, AKT protein, Animals, Antigens, Neoplasm - genetics, Antigens, Neoplasm - metabolism, Antimicrobial agents, Biomarkers, Tumor - genetics, Biomarkers, Tumor - metabolism, Cell Differentiation - genetics, Cell growth, Cell Proliferation, Differentiation, Epidermis - drug effects, Epidermis - injuries, Epidermis - metabolism, Gene Expression - drug effects, Humans, Inflammation, Injuries, Interleukin 17, Interleukin-17 - pharmacology, Intestine, Keratinocytes, Keratinocytes - cytology, Keratinocytes - drug effects, Keratinocytes - metabolism, Lectins, C-Type - genetics, Lectins, C-Type - metabolism, Mice, Mice, Inbred BALB C, Mice, Knockout, N-Acetylglucosaminyltransferases - metabolism, Pancreatitis-Associated Proteins, Phosphatidylinositol 3-Kinases - metabolism, Proteins - genetics, Proteins - metabolism, Proto-Oncogene Proteins c-akt - metabolism, Psoriasis, Psoriasis - immunology, Psoriasis - metabolism, Psoriasis - pathology, Rodents, Signal Transduction, Skin - drug effects, Skin - injuries, Skin - metabolism, Skin diseases, Wound healing, Wound Healing - genetics