Psychopharmacology, 2013-11, Vol.230 (1), p.89-111
2013
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- Autor(en) / Beteiligte
- Titel
- Noradrenergic versus dopaminergic modulation of impulsivity, attention and monitoring behaviour in rats performing the stop-signal task: Possible relevance to ADHD
- Ist Teil von
- Psychopharmacology, 2013-11, Vol.230 (1), p.89-111
- Ort / Verlag
- Berlin/Heidelberg: Springer Berlin Heidelberg
- Erscheinungsjahr
- 2013
- Quelle
- EBSCOhost Psychology and Behavioral Sciences Collection
- Beschreibungen/Notizen
- Rationale Deficient response inhibition is a prominent feature of many pathological conditions characterised by impulsive and compulsive behaviour. Clinically effective doses of catecholamine reuptake inhibitors are able to improve such inhibitory deficits as measured by the stop-signal task (SST) in humans and other animals. However, the precise therapeutic mode of action of these compounds in terms of their relative effects on dopamine (DA) and noradrenaline (NA) systems in prefrontal cortical and striatal regions mediating attention and cognitive control remains unclear. Objectives We sought to fractionate the effects of global catecholaminergic manipulations on SST performance by using receptor-specific compounds for NA or DA. The results are described in terms of the effects of modulating specific receptor subtypes on various behavioural measures such as response inhibition, perseveration, sustained attention, error monitoring and motivation. Results Blockade of α2-adrenoceptors improved sustained attention and response inhibition, whereas α1 and β1/2 adrenergic receptor antagonists disrupted go performance and sustained attention, respectively. No relevant effects were obtained after targeting DA D1, D2 or D4 receptors, while both a D3 receptor agonist and antagonist improved post-error slowing and compulsive nose-poke behaviour, though generally impairing other task measures. Conclusions Our results suggest that the use of specific pharmacological agents targeting α2 and β noradrenergic receptors may improve existing treatments for attentional deficits and impulsivity, whereas DA D3 receptors may modulate error monitoring and perseverative behaviour.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0033-3158eISSN: 1432-2072DOI: 10.1007/s00213-013-3141-6Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3824307
- Format
- –
- Schlagworte
- Animal behavior, Animals, Attention - drug effects, Attention Deficit Disorder with Hyperactivity - drug therapy, Attention Deficit Disorder with Hyperactivity - physiopathology, Attention-deficit hyperactivity disorder, Behavior, Animal - drug effects, Biomedical and Life Sciences, Biomedicine, Corpus Striatum - drug effects, Corpus Striatum - metabolism, Dopamine, Dopamine - metabolism, Drug therapy, Genetic aspects, Impulsive Behavior - drug therapy, Impulsive Behavior - physiopathology, Male, Motivation, Neurosciences, Noradrenaline, Norepinephrine - metabolism, Original Investigation, Pharmacology/Toxicology, Physiological aspects, Prefrontal Cortex - drug effects, Prefrontal Cortex - metabolism, Psychiatry, Psychopharmacology, Rats, Reaction Time - drug effects, Receptors, Adrenergic, alpha-2 - drug effects, Receptors, Adrenergic, alpha-2 - metabolism, Receptors, Adrenergic, beta - drug effects, Receptors, Adrenergic, beta - metabolism, Receptors, Dopamine - drug effects, Receptors, Dopamine - metabolism, Receptors, Dopamine D3 - drug effects, Receptors, Dopamine D3 - metabolism, Rodents