Nanomedicine (London, England), 2013-11, Vol.8 (11), p.1763-1776
2013
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- Autor(en) / Beteiligte
- Titel
- Poly( -caprolactone)-carbon nanotube composite scaffolds for enhanced cardiac differentiation of human mesenchymal stem cells
- Ist Teil von
- Nanomedicine (London, England), 2013-11, Vol.8 (11), p.1763-1776
- Ort / Verlag
- London: Future Medicine Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To evaluate the efficacy of electrically conductive, biocompatible composite scaffolds in modulating the cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs). Electrospun scaffolds of poly( -caprolactone) with or without carbon nanotubes were developed to promote the cardiac differentiation of hMSCs. Results indicate that hMSC differentiation can be enhanced by either culturing in electrically conductive, carbon nanotube-containing composite scaffolds without electrical stimulation in the presence of 5-azacytidine, or extrinsic electrical stimulation in nonconductive poly( -caprolactone) scaffolds without carbon nanotube and azacytidine. This study suggests a first step towards improving hMSC cardiomyogenic differentiation for local delivery into the infarcted myocardium. Original submitted 23 July 2012; Revised submitted 31 October 2012; Published online 27 March 2013
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1743-5889eISSN: 1748-6963DOI: 10.2217/nnm.12.204Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3809159
- Format
- –
- Schlagworte
- Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy, Applied cell therapy and gene therapy, Biological and medical sciences, carbon nanotube, cardiac differentiation, Care and treatment, Cell differentiation, Cell Differentiation - physiology, Cells, Cultured, Composite materials, Cross-disciplinary physics: materials science, rheology, electrical conductivity, Exact sciences and technology, Heart attack, Humans, Innovations, Materials science, Medical sciences, mesenchymal stem cell, Mesenchymal Stromal Cells - cytology, Nanoscale materials and structures: fabrication and characterization, Nanotechnology, Nanotubes, Carbon - chemistry, Observations, Physics, poly( -caprolactone), Polyesters - chemistry, Properties, Stem cells, Tissue Engineering - methods, Tissue Scaffolds - chemistry, Transfusions. Complications. Transfusion reactions. Cell and gene therapy