Details

Autor(en) / Beteiligte

• Miotto, Olivo
• Almagro-Garcia, Jacob
• Manske, Magnus
• MacInnis, Bronwyn
• Campino, Susana
• Rockett, Kirk A
• Amaratunga, Chanaki
• Lim, Pharath
• Suon, Seila
• Sreng, Sokunthea
• Anderson, Jennifer M
• Duong, Socheat
• Nguon, Chea
• Chuor, Char Meng
• Saunders, David
• Se, Youry
• Lon, Chantap
• Fukuda, Mark M
• Amenga-Etego, Lucas
• Hodgson, Abraham V O
• Asoala, Victor
• Imwong, Mallika
• Takala-Harrison, Shannon
• Nosten, François
• Su, Xin-zhuan
• Ringwald, Pascal
• Ariey, Frédéric
• Dolecek, Christiane
• Hien, Tran Tinh
• Boni, Maciej F
• Thai, Cao Quang
• Amambua-Ngwa, Alfred
• Conway, David J
• Djimdé, Abdoulaye A
• Doumbo, Ogobara K
• Zongo, Issaka
• Ouedraogo, Jean-Bosco
• Alcock, Daniel
• Drury, Eleanor
• Auburn, Sarah
• Koch, Oliver
• Sanders, Mandy
• Hubbart, Christina
• Maslen, Gareth
• Ruano-Rubio, Valentin
• Jyothi, Dushyanth
• Miles, Alistair
• O'Brien, John
• Gamble, Chris
• Oyola, Samuel O
• Rayner, Julian C
• Newbold, Chris I
• Berriman, Matthew
• Spencer, Chris C A
• McVean, Gilean
• Day, Nicholas P
• White, Nicholas J
• Bethell, Delia
• Dondorp, Arjen M
• Plowe, Christopher V
• Fairhurst, Rick M
• Kwiatkowski, Dominic P

Titel

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

Ist Teil von

• Nature genetics, 2013-06, Vol.45 (6), p.648-655

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Dominic Kwiatkowski and colleagues report analysis of genetic variation in 826 Plasmodium falciparum samples collected from 10 locations in West Africa and southeast Asia. They characterize the population structure of this parasite in Cambodia and find evidence for multiple distinct subpopulations showing high levels of genetic differentiation and artemisinin resistance. We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisinin resistance in western Cambodia. Within this relatively small geographic area, we have discovered several distinct but apparently sympatric parasite subpopulations with extremely high levels of genetic differentiation. Of particular interest are three subpopulations, all associated with clinical resistance to artemisinin, which have skewed allele frequency spectra and high levels of haplotype homozygosity, indicative of founder effects and recent population expansion. We provide a catalog of SNPs that show high levels of differentiation in the artemisinin-resistant subpopulations, including codon variants in transporter proteins and DNA mismatch repair proteins. These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination.