Angewandte Chemie (International ed.), 2013-03, Vol.52 (12), p.3379-3383
International ed. in English, 2013
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Details
- Autor(en) / Beteiligte
- Titel
- Polymer Nanofiber-Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells
- Ist Teil von
- Angewandte Chemie (International ed.), 2013-03, Vol.52 (12), p.3379-3383
- Auflage
- International ed. in English
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Confined to one cell: A method to detect and isolate single circulating melanoma cells (CMCs; see figure) has been produced by integrating a polymer‐nanofiber‐embedded nanovelcro cell‐affinity assay with a laser microdissection (LMD) technique. This method is able to separate CMCs from normal white blood cells (WBCs) and sequence individual cells for a specific mutation related to cancer progression, allowing for more personalized cancer therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1433-7851eISSN: 1521-3773DOI: 10.1002/anie.201208452Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3807678
- Format
- –
- Schlagworte
- Cancer, cancer diagnosis, Cell Line, Tumor, Cell Separation, Circulating, circulating tumor cells, Erythrocytes - cytology, Humans, Lactic Acid - chemistry, Lasers, melanoma, Melanoma - diagnosis, Melanoma - metabolism, Microfluidic Analytical Techniques, Mutation, Mutations, Nanofibers - chemistry, Nanostructure, Neoplastic Cells, Circulating - chemistry, Neoplastic Cells, Circulating - metabolism, Personalized, Polyglycolic Acid - chemistry, Polymers - chemistry, Progressions, Proto-Oncogene Proteins B-raf - genetics, Proto-Oncogene Proteins B-raf - metabolism, Single-Cell Analysis, White blood cells