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BibTeX
Genome-wide association uncovers shared genetic effects among personality traits and mood states
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2012-09, Vol.159B (6), p.684-695
Luciano, Michelle
Huffman, Jennifer E.
Arias-Vásquez, Alejandro
Vinkhuyzen, Anna A.E.
Middeldorp, Christel M.
Giegling, Ina
Payton, Antony
Davies, Gail
Zgaga, Lina
Janzing, Joost
Ke, Xiayi
Galesloot, Tessel
Hartmann, Annette M.
Ollier, William
Tenesa, Albert
Hayward, Caroline
Verhagen, Maaike
Montgomery, Grant W.
Hottenga, Jouke-Jan
Konte, Bettina
Starr, John M.
Vitart, Veronique
Vos, Pieter E.
Madden, Pamela A.F.
Willemsen, Gonneke
Konnerth, Heike
Horan, Michael A.
Porteous, David J.
Campbell, Harry
Vermeulen, Sita H.
Heath, Andrew C.
Wright, Alan
Polasek, Ozren
Kovacevic, Sanja B.
Hastie, Nicholas D.
Franke, Barbara
Boomsma, Dorret I.
Martin, Nicholas G.
Rujescu, Dan
Wilson, James F.
Buitelaar, Jan
Pendleton, Neil
Rudan, Igor
Deary, Ian J.
2012
Details
Autor(en) / Beteiligte
Luciano, Michelle
Huffman, Jennifer E.
Arias-Vásquez, Alejandro
Vinkhuyzen, Anna A.E.
Middeldorp, Christel M.
Giegling, Ina
Payton, Antony
Davies, Gail
Zgaga, Lina
Janzing, Joost
Ke, Xiayi
Galesloot, Tessel
Hartmann, Annette M.
Ollier, William
Tenesa, Albert
Hayward, Caroline
Verhagen, Maaike
Montgomery, Grant W.
Hottenga, Jouke-Jan
Konte, Bettina
Starr, John M.
Vitart, Veronique
Vos, Pieter E.
Madden, Pamela A.F.
Willemsen, Gonneke
Konnerth, Heike
Horan, Michael A.
Porteous, David J.
Campbell, Harry
Vermeulen, Sita H.
Heath, Andrew C.
Wright, Alan
Polasek, Ozren
Kovacevic, Sanja B.
Hastie, Nicholas D.
Franke, Barbara
Boomsma, Dorret I.
Martin, Nicholas G.
Rujescu, Dan
Wilson, James F.
Buitelaar, Jan
Pendleton, Neil
Rudan, Igor
Deary, Ian J.
Titel
Genome-wide association uncovers shared genetic effects among personality traits and mood states
Ist Teil von
American journal of medical genetics. Part B, Neuropsychiatric genetics, 2012-09, Vol.159B (6), p.684-695
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library Journals【Remote access available】
Beschreibungen/Notizen
Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome‐wide SNP (∼2.5 million) and gene‐based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546–1,338; maximum total n = 6,268) whose mean age ranged from 55 to 79 years. Meta‐analysis of the cohort results was performed, with follow‐up associations of the top SNPs and genes investigated in independent cohorts (n = 527–6,032). Suggestive association (P = 8 × 10−8) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P < 6.09 × 10−6) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress. An association between symptoms of depression and rs7582472 (near to MGAT5 and NCKAP5) was replicated in two independent samples, but other replication findings were less consistent. Gene‐based tests identified a significant locus on chromosome 15 (spanning five genes) associated with neuroticism which replicated (P < 0.05) in an independent cohort. Support for common genetic effects among personality and mood (particularly neuroticism and depressive symptoms) was found in terms of SNP association overlap and polygenic score prediction. The variance explained by individual SNPs was very small (up to 1%) confirming that there are no moderate/large effects of common SNPs on personality and related traits. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1552-4841
eISSN: 1552-485X
DOI: 10.1002/ajmg.b.32072
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3795298
Format
–
Schlagworte
Adolescent
,
Adult
,
Adult and adolescent clinical studies
,
Age
,
Aged
,
Aged, 80 and over
,
anxiety
,
Anxiety - genetics
,
Biological and medical sciences
,
Cohort Studies
,
Depression
,
Depression - genetics
,
extraversion
,
Extraversion, Psychological
,
Female
,
Genetic Predisposition to Disease
,
Genetics
,
Genome-Wide Association Study
,
GWAS
,
Humans
,
Male
,
Medical genetics
,
Medical sciences
,
Middle Aged
,
Miscellaneous
,
Mood disorders
,
Mood Disorders - genetics
,
Neuropsychological Tests
,
Neurotic Disorders - genetics
,
neuroticism
,
Personality - genetics
,
Polymorphism, Single Nucleotide - genetics
,
Psychology. Psychoanalysis. Psychiatry
,
Psychopathology. Psychiatry
,
Reproducibility of Results
,
Young Adult
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