Details
- Autor(en) / Beteiligte
- Titel
- PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
- Ist Teil von
- Oncogene, 2009-01, Vol.28 (2), p.306-312
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Immune escape describes a critical event whereby tumor cells adopt an immunoresistant phenotype to escape adaptive surveillance. We show that expression of a pivotal negative regulator of T-cell function, B7-H1, correlates with PI(3) kinase activation in breast and prostate cancer patients. B7-H1-mediated immunoresistance can be attenuated by inhibitors of the PI(3) kinase pathway, and is dependent on S6K1-mediated translational regulation of B7-H1 protein. Breast and prostate carcinoma cells with activated PI(3) kinase lose the immunoresistant phenotype after treatment with B7-H1 siRNA. Conversely, breast and prostate carcinoma cells with minimal PI(3) kinase activation adopt an immunoresistant phenotype when engineered to overexpress B7-H1 protein. These observations describe a mechanism for immune escape from tumor dormancy in humans that relates to oncogenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0950-9232eISSN: 1476-5594DOI: 10.1038/onc.2008.384Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3786571
- Format
- –
- Schlagworte
- Adenocarcinoma - enzymology, Adenocarcinoma - immunology, Adenocarcinoma - pathology, Antigens, CD - genetics, Antigens, CD - physiology, B7-H1 Antigen, Biological and medical sciences, Breast cancer, Breast Neoplasms - enzymology, Breast Neoplasms - immunology, Breast Neoplasms - pathology, Care and treatment, Cell Line, Tumor - drug effects, Cell Line, Tumor - enzymology, Cell Line, Tumor - immunology, Cell physiology, Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes, Female, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Genetic aspects, Genotype & phenotype, Gynecology. Andrology. Obstetrics, Health aspects, Humans, Immune response, Immune system, Kinases, Leukocytes, Male, Mammary gland diseases, Medical sciences, Molecular and cellular biology, Neoplasm Proteins - antagonists & inhibitors, Neoplasm Proteins - genetics, Neoplasm Proteins - physiology, Nephrology. Urinary tract diseases, Oncology, Phenotype, Phosphatidylinositol 3-Kinases - antagonists & inhibitors, Phosphatidylinositol 3-Kinases - physiology, Prostate cancer, Prostatic Neoplasms - enzymology, Prostatic Neoplasms - immunology, Prostatic Neoplasms - pathology, Protein Kinase Inhibitors - pharmacology, Protein kinases, PTEN Phosphohydrolase - physiology, Recombinant Fusion Proteins - physiology, Ribosomal Protein S6 Kinases - physiology, RNA, Small Interfering - pharmacology, T-Lymphocytes, Cytotoxic - immunology, Tumor Escape - drug effects, Tumor Escape - genetics, Tumor Escape - immunology, Tumors, Tumors of the urinary system, Urinary tract. Prostate gland