Details

Autor(en) / Beteiligte

• Gildea, John J.
• Carlson, Julia M.
• Schoeffel, Cynthia D.
• Carey, Robert M.
• Felder, Robin A.

Titel

Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure

Ist Teil von

• Clinical biochemistry, 2013-08, Vol.46 (12), p.1131-1134

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate microRNAs (miRNAs) in urinary exosomes and their association with an individual's blood pressure response to dietary salt intake. Human urinary exosomal miRNome was examined by microarray. Of 1898 probes tested, 194 miRNAs were found in all subjects tested. 45 miRNAs had significant associations with salt sensitivity or inverse salt sensitivity. The expression of 45 urinary exosomal miRNAs associates with an individual's blood pressure response to sodium. •Biomarkers are needed to determine an individual's salt sensitivity index.•Urinary exosomes contain miRNA originating exclusively from the kidney.•Distinct patterns of miRNA are associated with individual salt sensitivity indices.