Cold Spring Harbor perspectives in medicine, 2013-10, Vol.3 (10), p.a014415-a014415
2013
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- Autor(en) / Beteiligte
- Titel
- Neuroblastoma and MYCN
- Ist Teil von
- Cold Spring Harbor perspectives in medicine, 2013-10, Vol.3 (10), p.a014415-a014415
- Ort / Verlag
- United States: Cold Spring Harbor Laboratory Press
- Erscheinungsjahr
- 2013
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2157-1422eISSN: 2157-1422, 2472-5412DOI: 10.1101/cshperspect.a014415Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3784814
- Format
- –
- Schlagworte
- Antigens, Neoplasm - genetics, Antigens, Neoplasm - immunology, Apoptosis - genetics, Cell Cycle - genetics, Cell Proliferation, Gene Amplification - genetics, Gene Expression, Genes, myc - genetics, Genetic Markers - genetics, Humans, Mutation - genetics, N-Myc Proto-Oncogene Protein, Neoplasm Metastasis, Neovascularization, Pathologic - genetics, Neuroblastoma - genetics, Neuroblastoma - pathology, Nuclear Proteins - genetics, Oncogene Proteins - genetics, Protein Stability, Risk Factors, Transcription, Genetic - genetics