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Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression
International journal of geriatric psychiatry, 2013-09, Vol.28 (9), p.925-932
Jamerson, Brenda D.
Payne, Martha E.
Garrett, Melanie E.
Ashley-Koch, Allison E.
Speer, Marcy C.
Steffens, David C.
2013
Details
Autor(en) / Beteiligte
Jamerson, Brenda D.
Payne, Martha E.
Garrett, Melanie E.
Ashley-Koch, Allison E.
Speer, Marcy C.
Steffens, David C.
Titel
Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression
Ist Teil von
International journal of geriatric psychiatry, 2013-09, Vol.28 (9), p.925-932
Ort / Verlag
Hove: Blackwell Publishing Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Objective The primary aims of this study were to (i) determine whether folate metabolism genetic polymorphisms predict age of onset and occurrence of late life depression; and (ii) determine whether folate metabolism genetic polymorphisms predict response to antidepressant medications in late‐life depression. Methods This study used the Conte Center for the Neuroscience of Depression and the Neurocognitive Outcomes of Depression in the Elderly Study database, which includes individuals aged ≥60. The folate nutrition assessment was determined by the Block Food Frequency Questionnaire. Genotype was evaluated for 15 single nucleotide polymorphisms from 10 folate metabolism genes. Logistic regression models were used to examine genetic polymorphisms and folate estimates with association with depression age of onset and remission status. Results There were 304 Caucasians in the database, 106 of these were not depressed and 198 had a diagnosis of depression. There were no significant differences between remitters and non‐remitters in age, sex or estimated folate intakes. There were no folate estimates or folate metabolism gene single nucleotide polymorphisms that significantly predicted age of onset of depression or occurrence of depression. Methionine synthase reductase (MTRR) A66G (rs1801394) was significantly associated with remission status (p = 0.0077) such that those with the AA genotype were 3.2 times as likely as those with the GG genotype to be in remission (p = 0.0020). Methylenetetrahydrofolate reductase A1298C (rs1801131) achieved a borderline significance for association with remission status (p = 0.0313). Conclusion The major finding from this study is that the MTRR A66G genotype predicts response to selective serotonin reuptake inhibitor antidepressants in late life depression. Copyright © 2012 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0885-6230
eISSN: 1099-1166
DOI: 10.1002/gps.3899
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3779127
Format
–
Schlagworte
5-Methyltetrahydrofolate-homocysteine S-methyltransferase
,
Adult and adolescent clinical studies
,
Age of Onset
,
Aged
,
Antidepressants
,
Antidepressive Agents - therapeutic use
,
Biological and medical sciences
,
Cystathionine beta-Synthase - genetics
,
Depression
,
Depressive Disorder - drug therapy
,
Depressive Disorder - genetics
,
Diet
,
Female
,
Ferredoxin-NADP Reductase - genetics
,
folate
,
Folic Acid - administration & dosage
,
Folic Acid - genetics
,
Folic Acid - metabolism
,
General aspects
,
Genetic Predisposition to Disease
,
Genotype
,
Geriatric psychiatry
,
Geriatrics
,
Glycine Hydroxymethyltransferase - genetics
,
Humans
,
late-life depression
,
Logistic Models
,
Male
,
Medical sciences
,
Mental depression
,
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
,
Middle Aged
,
Mood disorders
,
Older people
,
Polymorphism, Single Nucleotide - genetics
,
Predictive Value of Tests
,
Psychology. Psychoanalysis. Psychiatry
,
Psychopathology. Psychiatry
,
Serotonin
,
Serotonin Uptake Inhibitors - therapeutic use
,
single nucleotide polymorphisms
,
Studies
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