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Mapping white matter integrity in elderly people with HIV
Human brain mapping, 2014-03, Vol.35 (3), p.975-992
Nir, Talia M.
Jahanshad, Neda
Busovaca, Edgar
Wendelken, Lauren
Nicolas, Krista
Thompson, Paul M.
Valcour, Victor G.
2014
Details
Autor(en) / Beteiligte
Nir, Talia M.
Jahanshad, Neda
Busovaca, Edgar
Wendelken, Lauren
Nicolas, Krista
Thompson, Paul M.
Valcour, Victor G.
Titel
Mapping white matter integrity in elderly people with HIV
Ist Teil von
Human brain mapping, 2014-03, Vol.35 (3), p.975-992
Ort / Verlag
New York, NY: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Electronic Journals Library
Beschreibungen/Notizen
People with HIV are living longer as combination antiretroviral therapy (cART) becomes more widely available. However, even when plasma viral load is reduced to untraceable levels, chronic HIV infection is associated with neurological deficits and brain atrophy beyond that of normal aging. HIV is often marked by cortical and subcortical atrophy, but the integrity of the brain's white matter (WM) pathways also progressively declines. Few studies focus on older cohorts where normal aging may be compounded with HIV infection to influence deficit patterns. In this relatively large diffusion tensor imaging (DTI) study, we investigated abnormalities in WM fiber integrity in 56 HIV+ adults with access to cART (mean age: 63.9 ± 3.7 years), compared to 31 matched healthy controls (65.4 ± 2.2 years). Statistical 3D maps revealed the independent effects of HIV diagnosis and age on fractional anisotropy (FA) and diffusivity, but we did not find any evidence for an age by diagnosis interaction in our current sample. Compared to healthy controls, HIV patients showed pervasive FA decreases and diffusivity increases throughout WM. We also assessed neuropsychological (NP) summary z‐score associations. In both patients and controls, fiber integrity measures were associated with NP summary scores. The greatest differences were detected in the corpus callosum and in the projection fibers of the corona radiata. These deficits are consistent with published NP deficits and cortical atrophy patterns in elderly people with HIV. Hum Brain Mapp 35:975–992, 2014. © 2013 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.22228
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3775847
Format
–
Schlagworte
Aged
,
Aging - pathology
,
Aging - physiology
,
Anti-HIV Agents - therapeutic use
,
Antiretroviral Therapy, Highly Active
,
Atrophy - pathology
,
Biological and medical sciences
,
brain integrity
,
cART
,
cognition
,
Corpus Callosum - pathology
,
diffusion tensor imaging
,
Diffusion Tensor Imaging - instrumentation
,
Diffusion Tensor Imaging - methods
,
Female
,
HIV
,
HIV Infections - drug therapy
,
HIV Infections - pathology
,
HIV Infections - physiopathology
,
Humans
,
Investigative techniques, diagnostic techniques (general aspects)
,
Leukoencephalopathies - pathology
,
Leukoencephalopathies - physiopathology
,
Male
,
Medical sciences
,
Middle Aged
,
Nerve Fibers - pathology
,
Nervous system
,
Neuropsychological Tests - statistics & numerical data
,
Radiodiagnosis. Nmr imagery. Nmr spectrometry
,
Radionuclide investigations
,
white matter
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