Vaccine, 2012-11, Vol.30 (49), p.7040-7045
2012
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- Autor(en) / Beteiligte
- Titel
- Establishment of a Shigella sonnei human challenge model in Thailand
- Ist Teil von
- Vaccine, 2012-11, Vol.30 (49), p.7040-7045
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► A Shigella sonnei human challenge model was established in a less developed country. ► 1600 CFU of S. sonnei elicited clinical disease in 75% of Thai adult volunteers. ► The required S. sonnei challenge dose in Thailand was greater than in U.S. studies. ► The challenge model will provide an opportunity for S. sonnei vaccines evaluation in endemic populations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2012.09.061Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3732056
- Format
- –
- Schlagworte
- Adult, adults, Allergy and Immunology, Bacterial Load, Dysentery, Bacillary - pathology, Dysentery, Bacillary - prevention & control, Female, Human challenge model, Humans, Male, Shigella, Shigella sonnei, Shigella sonnei - immunology, Shigella sonnei - pathogenicity, Shigella vaccine, Shigella Vaccines - immunology, Thailand, vaccines, volunteers, Young Adult