Details

Autor(en) / Beteiligte

• Covarrubias, Anthony
• Byles, Vanessa
• Horng, Tiffany

Titel

ROS sets the stage for macrophage differentiation

Ist Teil von

• Cell research, 2013-08, Vol.23 (8), p.984-985

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tu- mor associated macrophages （TAMs） regulate tissue remodeling and angio- genesis and can display immunomod- ulatory activity. In July issue of Cell Research, Zhang et aL show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.