Nature communications, 2013-01, Vol.4 (1), p.1393-1393, Article 1393
2013
Details
- Autor(en) / Beteiligte
- Titel
- MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11
- Ist Teil von
- Nature communications, 2013-01, Vol.4 (1), p.1393-1393, Article 1393
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chemotherapy resistance frequently drives tumour progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition has been shown to correlate with therapy resistance, but the functional link and signalling pathways remain to be elucidated. Here we report that microRNA-30c, a human breast tumour prognostic marker, has a pivotal role in chemoresistance by a direct targeting of the actin-binding protein twinfilin 1, which promotes epithelial-to-mesenchymal transition. An interleukin-6 family member, interleukin-11 is identified as a secondary target of twinfilin 1 in the microRNA-30c signalling pathway. Expression of microRNA-30c inversely correlates with interleukin-11 expression in primary breast tumours and low interleukin-11 correlates with relapse-free survival in breast cancer patients. Our study demonstrates that microRNA-30c is transcriptionally regulated by GATA3 in breast tumours. Identification of a novel microRNA-mediated pathway that regulates chemoresistance in breast cancer will facilitate the development of novel therapeutic strategies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/ncomms2393Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3723106
- Format
- –
- Schlagworte
- Animals, Biomarkers, Biomarkers, Tumor - metabolism, Breast cancer, Breast Neoplasms - drug therapy, Breast Neoplasms - genetics, Breast Neoplasms - pathology, Cancer therapies, Cell Line, Tumor, Cell Survival - drug effects, Cell Survival - genetics, Chemotherapy, Cluster Analysis, Cytokines, Cytoskeleton - drug effects, Cytoskeleton - genetics, Doxorubicin - pharmacology, Doxorubicin - therapeutic use, Drug dosages, Drug resistance, Drug Resistance, Neoplasm - drug effects, Drug Resistance, Neoplasm - genetics, Epithelial-Mesenchymal Transition - drug effects, Epithelial-Mesenchymal Transition - genetics, Female, GATA3 Transcription Factor - metabolism, Gene Expression Profiling, Gene Expression Regulation, Neoplastic - drug effects, Humans, Interleukin-11 - genetics, Interleukin-11 - metabolism, Mice, Microfilament Proteins - genetics, Microfilament Proteins - metabolism, MicroRNAs, MicroRNAs - metabolism, Prognosis, Protein-Tyrosine Kinases - genetics, Protein-Tyrosine Kinases - metabolism, Real-Time Polymerase Chain Reaction, Stem cells, Suppression, Genetic - drug effects, Tumors, Xenograft Model Antitumor Assays