Details

Autor(en) / Beteiligte

• Tang, W.H. Wilson
• Wang, Zeneng
• Levison, Bruce S
• Koeth, Robert A
• Britt, Earl B
• Fu, Xiaoming
• Wu, Yuping
• Hazen, Stanley L

Titel

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

Ist Teil von

• The New England journal of medicine, 2013-04, Vol.368 (17), p.1575-1584

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2013

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• The production of trimethylamine-N-oxide (TMAO) from dietary phosphatidylcholine was found to be dependent on metabolism by the intestinal microbiota. Increased TMAO levels were associated with an increased risk of incident major adverse cardiac events. The phospholipid phosphatidylcholine (lecithin) is the major dietary source of choline, a semiessential nutrient that is part of the B-complex vitamin family. 1 , 2 Choline has various metabolic roles, ranging from its essential involvement in lipid metabolism and cell-membrane structure to its role as a precursor for the synthesis of the neurotransmitter acetylcholine. Choline and some of its metabolites, such as betaine, can also serve as a source of methyl groups that are required for proper metabolism of certain amino acids, such as homocysteine and methionine. 3 There is a growing awareness that intestinal microbial organisms, collectively termed microbiota, participate in the . . .