Details

Autor(en) / Beteiligte

• Aachoui, Youssef
• Leaf, Irina A.
• Hagar, Jon A.
• Fontana, Mary F.
• Campos, Cristine G.
• Zak, Daniel E.
• Tan, Michael H.
• Cotter, Peggy A.
• Vance, Russell E.
• Aderem, Alan
• Miao, Edward A.

Titel

Caspase-11 Protects Against Bacteria That Escape the Vacuole

Ist Teil von

• Science (American Association for the Advancement of Science), 2013-02, Vol.339 (6122), p.975-978

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2013

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1 has an established protective role during infection. Here, we report that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria. Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, specific mutants (sifA and sdhA, respectively) aberrantly enter the cytosol. These mutants triggered caspase-11, which enhanced clearance of S. typhimurium sifA in vivo. This response did not require NLRP3, NLRC4, or ASC inflammasome pathways. Burkholderia species that naturally invade the cytosol also triggered caspase-11, which protected mice from lethal challenge with B. thailandensis and B. pseudomallei. Thus, caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens.