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BibTeX
Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2
Journal of magnetic resonance imaging, 2013-11, Vol.38 (5), p.1177-1183
Thomas, Binu P.
Yezhuvath, Uma S.
Tseng, Benjamin Y.
Liu, Peiying
Levine, Benjamin D.
Zhang, Rong
Lu, Hanzhang
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Thomas, Binu P.
Yezhuvath, Uma S.
Tseng, Benjamin Y.
Liu, Peiying
Levine, Benjamin D.
Zhang, Rong
Lu, Hanzhang
Titel
Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2
Ist Teil von
Journal of magnetic resonance imaging, 2013-11, Vol.38 (5), p.1177-1183
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2013
Quelle
MEDLINE
Beschreibungen/Notizen
Purpose To examine the potential benefits of life‐long aerobic exercise on brain health, in particular cerebrovascular function. Materials and Methods Ten Masters athletes (MA) (seven males, three females; 74.5 ± 5.8 years) and 10 sedentary elderly individuals (SE) (eight males, two females; 75.4 ± 5.6 years) were recruited and baseline cerebral blood flow (CBF) and cerebral vascular reactivity (CVR) to CO2 were measured on a 3T MRI scanner. Nine sedentary young subjects were also recruited to serve as a control group to verify the age effect. Results When compared to the SE group, MA showed higher CBF in posterior cingulate cortex/precuneus, which are key regions of the default‐mode‐network and are known to be highly sensitive to age and dementia. CVR in the MA brains were paradoxically lower than that in SE. This effect was present throughout the brain. Within the MA group, individuals with higher VO2max had an even lower CVR, suggesting a dose–response relationship. Conclusion Life‐long aerobic exercise preserved blood supply in the brain's default‐mode‐network against age‐related degradation. On the other hand, its impact on the cerebral vascular system seems to be characterized by a dampening of CO2 reactivity, possibly because of desensitization effects due to a higher lifetime exposure. J. Magn. Reson. Imaging 2013;38:1177–1183. © 2013 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1053-1807
eISSN: 1522-2586
DOI: 10.1002/jmri.24090
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3695025
Format
–
Schlagworte
Aging - drug effects
,
Aging - physiology
,
arterial-spin-labeling
,
Blood Flow Velocity - physiology
,
BOLD MRI
,
Carbon Dioxide - administration & dosage
,
cerebral blood flow
,
cerebral vascular reactivity
,
Cerebrovascular Circulation - drug effects
,
Cerebrovascular Circulation - physiology
,
CO2
,
Exercise - physiology
,
Female
,
Humans
,
Magnetic resonance imaging
,
Male
,
masters athletes
,
Middle Aged
,
Physical Fitness - physiology
,
Sedentary Lifestyle
,
Sports - physiology
,
Vascular Resistance - drug effects
,
Vascular Resistance - physiology
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