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Factors associated with kyphosis progression in older women: 15 years' experience in the study of osteoporotic fractures
Journal of bone and mineral research, 2013-01, Vol.28 (1), p.179-187
Kado, Deborah M
Huang, Mei‐Hua
Karlamangla, Arun S
Cawthon, Peggy
Katzman, Wendy
Hillier, Teresa A
Ensrud, Kristine
Cummings, Steven R
2013
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Kado, Deborah M
Huang, Mei‐Hua
Karlamangla, Arun S
Cawthon, Peggy
Katzman, Wendy
Hillier, Teresa A
Ensrud, Kristine
Cummings, Steven R
Titel
Factors associated with kyphosis progression in older women: 15 years' experience in the study of osteoporotic fractures
Ist Teil von
Journal of bone and mineral research, 2013-01, Vol.28 (1), p.179-187
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2013
Quelle
EZB-FREE-00999 freely available EZB journals
Beschreibungen/Notizen
Age‐related hyperkyphosis is thought to be a result of underlying vertebral fractures, but studies suggest that among the most hyperkyphotic women, only one in three have underlying radiographic vertebral fractures. Although commonly observed, there is no widely accepted definition of hyperkyphosis in older persons, and other than vertebral fracture, no major causes have been identified. To identify important correlates of kyphosis and risk factors for its progression over time, we conducted a 15‐year retrospective cohort study of 1196 women, aged 65 years and older at baseline (1986 to 1988), from four communities across the United States: Baltimore County, MD; Minneapolis, MN; Portland, OR; and the Monongahela Valley, PA. Cobb angle kyphosis was measured from radiographs obtained at baseline and an average of 3.7 and 15 years later. Repeated measures, mixed effects analyses were performed. At baseline, the mean kyphosis angle was 44.7 degrees (SE = 0.4, SD = 11.9) and significant correlates included a family history of hyperkyphosis, prevalent vertebral fracture, low bone mineral density, greater body weight, degenerative disc disease, and smoking. Over an average of 15 years, the mean increase in kyphosis was 7.1 degrees (SE = 0.25). Independent determinants of greater kyphosis progression were prevalent and incident vertebral fractures, low bone mineral density and concurrent bone density loss, low body weight, and concurrent weight loss. Thus, age‐related kyphosis progression may be best prevented by slowing bone density loss and avoiding weight loss. © 2013 American Society for Bone and Mineral Research
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.1728
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3693545
Format
–
Schlagworte
Age
,
Aged
,
Body weight
,
Bone mineral density
,
CAUSES
,
Cohort Studies
,
Disease Progression
,
Female
,
Fractures
,
Humans
,
HUNCHBACK
,
HYPERKYPHOSIS
,
KYPHOSIS
,
Kyphosis - complications
,
Kyphosis - epidemiology
,
Kyphosis - pathology
,
KYPHOTIC POSTURE
,
Models, Biological
,
Multivariate Analysis
,
Osteoporosis
,
Osteoporotic Fractures - complications
,
Osteoporotic Fractures - epidemiology
,
Osteoporotic Fractures - pathology
,
Radiography
,
Risk Factors
,
Smoking
,
Time Factors
,
United States - epidemiology
,
Vertebrae
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