Details

Autor(en) / Beteiligte

• Bart, Bradley A
• Goldsmith, Steven R
• Lee, Kerry L
• Givertz, Michael M
• O'Connor, Christopher M
• Bull, David A
• Redfield, Margaret M
• Deswal, Anita
• Rouleau, Jean L
• LeWinter, Martin M
• Ofili, Elizabeth O
• Stevenson, Lynne W
• Semigran, Marc J
• Felker, G. Michael
• Chen, Horng H
• Hernandez, Adrian F
• Anstrom, Kevin J
• McNulty, Steven E
• Velazquez, Eric J
• Ibarra, Jenny C
• Mascette, Alice M
• Braunwald, Eugene

Titel

Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome

Ist Teil von

• The New England journal of medicine, 2012-12, Vol.367 (24), p.2296-2304

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Patients with decompensated heart failure and cardiorenal syndrome were randomly assigned to ultrafiltration or diuretic therapy. Ultrafiltration was inferior to diuretics with respect to the primary end point, a bivariate measure of change in creatinine and body weight. The acute cardiorenal syndrome (type 1) is defined as worsening renal function in patients with acute decompensated heart failure. 1 It occurs in 25 to 33% of patients with acute decompensated heart failure and is associated with poor outcomes. 1 , 2 Multiple processes contribute to the development of the acute cardiorenal syndrome, including extrarenal hemodynamic changes, neurohormonal activation, intrarenal microvascular and cellular dysregulation, and oxidative stress. 1 In some cases, intravenous diuretics, which are often administered in patients with acute decompensated heart failure, 3 may directly contribute to worsening renal function. 1 , 4 , 5 The use of diuretics to treat persistent congestion after the onset . . .