Science (American Association for the Advancement of Science), 2007-07, Vol.317 (5834), p.130-132
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells
- Ist Teil von
- Science (American Association for the Advancement of Science), 2007-07, Vol.317 (5834), p.130-132
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The airway epithelium plays an essential role in innate immunity to lung pathogens. Ribonucleoprotein particles primarily composed of major vault protein (MVP) are highly expressed in cells that encounter xenobiotics. However, a clear biologic function for MVP is not established. We report here that MVP is rapidly recruited to lipid rafts when human lung epithelial cells are infected with Pseudomonas aeruginosa, and maximal recruitment is dependent on bacterial binding to the cystic fibrosis transmembrane conductance regulator. MVP was also essential for optimal epithelial cell internalization and clearance of P. aeruginosa. These results suggest that MVP makes a substantial contribution to epithelial cell-mediated resistance to infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1142311Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3685177
- Format
- –
- Schlagworte
- Animals, Bacteria, Bacteriology, Biological and medical sciences, Cell lines, Cellular biology, Cystic Fibrosis Transmembrane Conductance Regulator - genetics, Cystic Fibrosis Transmembrane Conductance Regulator - metabolism, Epithelial cells, Epithelial Cells - metabolism, Epithelial Cells - microbiology, Fundamental and applied biological sciences. Psychology, Humans, Immunity, Innate, Immunology, Infections, Innate immunity, Lipids, Lung - immunology, Lung - microbiology, Lung Diseases - immunology, Lung Diseases - metabolism, Lung Diseases - microbiology, Lungs, Membrane Microdomains - metabolism, Mice, Microbiology, Mitral valve prolapse, Molecular biology, Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains, Proteins, Pseudomonas aeruginosa, Pseudomonas aeruginosa - immunology, Pseudomonas aeruginosa - metabolism, Pseudomonas Infections - immunology, Pseudomonas Infections - metabolism, Pseudomonas Infections - microbiology, Rafts, Respiratory Mucosa - immunology, Respiratory Mucosa - metabolism, Respiratory Mucosa - microbiology, RNA, Small Interfering - genetics, Signal Transduction, Small interfering RNA, Vault Ribonucleoprotein Particles - physiology