Details

Autor(en) / Beteiligte

• Holt, S
• Bertelli, G
• Humphreys, I
• Valentine, W
• Durrani, S
• Pudney, D
• Rolles, M
• Moe, M
• Khawaja, S
• Sharaiha, Y
• Brinkworth, E
• Whelan, S
• Jones, S
• Bennett, H
• Phillips, C J

Titel

A decision impact, decision conflict and economic assessment of routine Oncotype DX testing of 146 women with node-negative or pNImi, ER-positive breast cancer in the UK

Ist Teil von

• British journal of cancer, 2013-06, Vol.108 (11), p.2250-2258

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: Tumour gene expression analysis is useful in predicting adjuvant chemotherapy benefit in early breast cancer patients. This study aims to examine the implications of routine Onco type DX testing in the UK. Methods: Women with oestrogen receptor positive (ER+), pNO or pN1mi breast cancer were assessed for adjuvant chemotherapy and subsequently offered Onco type DX testing, with changes in chemotherapy decisions recorded. A subset of patients completed questionnaires about their uncertainties regarding chemotherapy decisions pre- and post-testing. All patients were asked to complete a diary of medical interactions over the next 6 months, from which economic data were extracted to model the cost-effectiveness of testing. Results: Onco type DX testing resulted in changes in chemotherapy decisions in 38 of 142 (26.8%) women, with 26 of 57 (45.6%) spared chemotherapy and 12 of 85 (14.1%) requiring chemotherapy when not initially recommended (9.9% reduction overall). Decision conflict analysis showed that Onco type DX testing increased patients’ confidence in treatment decision making. Economic analysis showed that routine Onco type DX testing costs £6232 per quality-adjusted life year gained. Conclusion: Onco type DX decreased chemotherapy use and increased confidence in treatment decision making in patients with ER+ early-stage breast cancer. Based on these findings, Onco type DX is cost-effective in the UK setting.