Details

Autor(en) / Beteiligte

• KORN, Ronald L
• CROWLEY, John J

Titel

Overview: Progression-Free Survival as an Endpoint in Clinical Trials with Solid Tumors

Ist Teil von

• Clinical cancer research, 2013-05, Vol.19 (10), p.2607-2612

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Progression-free survival (PFS) is increasingly used as an important and even a primary endpoint in randomized cancer clinical trials in the evaluation of patients with solid tumors for both practical and clinical considerations. Although in its simplest form, PFS is the time from randomization to a predefined endpoint, there are many factors that can influence the exact moment of when disease progression is recorded. In this overview, we review the circumstances that can devalue the use of PFS as a primary endpoint and attempt to provide a pathway for a future desired state when PFS will become not just a secondary alternative to overall survival but rather an endpoint of choice.