Details

Autor(en) / Beteiligte

• HOLLIDAY, Elizabeth G
• MAGUIRE, Jane M
• MALIK, Rainer
• MCEVOY, Mark
• BIROS, Erik
• LEWIS, Martin D
• LINCZ, Lisa F
• PEEL, Roseanne
• OLDMEADOW, Christopher
• SMITH, Wayne
• MOSCATO, Pablo
• BARLERA, Simona
• EVANS, Tiffany-Jane
• BEVAN, Steve
• BIS, Joshua C
• BOERWINKLE, Eric
• BONCORAGLIO, Giorgio B
• BROTT, Thomas G
• BROWN, Robert D
• CHENG, Yu-Ching
• COLE, John W
• COTLARCIUC, Ioana
• DEVAN, William J
• KOBLAR, Simon A
• FORNAGE, Myriam
• FURIE, Karen L
• GRETARSDOTTIR, Sólveig
• GSCHWENDTNER, Andreas
• IKRAM, M. Arfan
• LONGSTRETH, W. T
• MESCHIA, James F
• MITCHELL, Braxton D
• MOSLEY, Thomas H
• NAILS, Michael A
• JANNES, Jim
• PARATI, Eugenio A
• PSATY, Bruce M
• SHARMA, Pankaj
• STEFANSSON, Kari
• THORLEIFSSON, Gudmar
• THORSTEINSDOTTIR, Unnur
• TRAYLOR, Matthew
• VERHAAREN, Benjamin F. J
• WIGGINS, Kerri L
• WORRALL, Bradford B
• STURM, Jonathan W
• SUDLOW, Cathie
• ROTHWELL, Peter M
• FARRALL, Martin
• DICHGANS, Martin
• ROSAND, Jonathan
• MARKUS, Hugh S
• SCOTT, Rodney J
• LEVI, Christopher
• ATTIA, John
• HANKEY, Graeme J
• BAKER, Ross
• GOLLEDGE, Jonathan
• PARSONS, Mark W

Titel

Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

Ist Teil von

• Nature genetics, 2012-10, Vol.44 (10), p.1147-1151

Ort / Verlag

New York, NY: Nature Publishing Group

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Genome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR)=1.62, P=3.9×10(-8)) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR=1.15, P=3.9×10(-4); discovery and replication combined OR=1.21, P=4.7×10(-8)). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.