BMC bioinformatics, 2013-02, Vol.14 (1), p.58-58, Article 58
2013
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- Autor(en) / Beteiligte
- Titel
- Prediction of a time-to-event trait using genome wide SNP data
- Ist Teil von
- BMC bioinformatics, 2013-02, Vol.14 (1), p.58-58, Article 58
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A popular objective of many high-throughput genome projects is to discover various genomic markers associated with traits and develop statistical models to predict traits of future patients based on marker values. In this paper, we present a prediction method for time-to-event traits using genome-wide single-nucleotide polymorphisms (SNPs). We also propose a MaxTest associating between a time-to-event trait and a SNP accounting for its possible genetic models. The proposed MaxTest can help screen out nonprognostic SNPs and identify genetic models of prognostic SNPs. The performance of the proposed method is evaluated through simulations. In conjunction with the MaxTest, the proposed method provides more parsimonious prediction models but includes more prognostic SNPs than some naive prediction methods. The proposed method is demonstrated with real GWAS data.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1471-2105eISSN: 1471-2105DOI: 10.1186/1471-2105-14-58Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3651372
- Format
- –
- Schlagworte
- Algorithms, Cancer, Genetic aspects, Genetic research, Genetics, Genome-wide association studies, Genome-Wide Association Study - methods, Genomics, Humans, Leukemia, Myeloid, Acute - genetics, Leukemia, Myeloid, Acute - mortality, Medical research, Medicine, Experimental, Methodology, Methods, Models, Genetic, Oncology, Experimental, Polymorphism, Single Nucleotide, Proportional Hazards Models, Single nucleotide polymorphisms, Statistical analysis, Studies