Details

Autor(en) / Beteiligte

• Yanger, Kilangsungla
• Zong, Yiwei
• Maggs, Lara R
• Shapira, Suzanne N
• Maddipati, Ravi
• Aiello, Nicole M
• Thung, Swan N
• Wells, Rebecca G
• Greenbaum, Linda E
• Stanger, Ben Z

Titel

Robust cellular reprogramming occurs spontaneously during liver regeneration

Ist Teil von

• Genes & development, 2013-04, Vol.27 (7), p.719-724

Ort / Verlag

United States: Cold Spring Harbor Laboratory Press

Erscheinungsjahr

2013

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine. However, this phenomenon has rarely been observed in vivo without exogenous factors. Here, we report that activation of Notch, a signaling pathway that mediates lineage segregation during liver development, is sufficient to reprogram hepatocytes into biliary epithelial cells (BECs). Moreover, using lineage tracing, we show that hepatocytes undergo widespread hepatocyte-to-BEC reprogramming following injuries that provoke a biliary response, a process requiring Notch. These results provide direct evidence that mammalian regeneration prompts extensive and dramatic changes in cellular identity under injury conditions.