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Height loss in older women: Risk of hip fracture and mortality independent of vertebral fractures
Journal of bone and mineral research, 2012-01, Vol.27 (1), p.153-159
Hillier, Teresa A
Lui, Li-Yung
Kado, Deborah M
LeBlanc, ES
Vesco, Kimberly K
Bauer, Douglas C
Cauley, Jane A
Ensrud, Kristine E
Black, Dennis M
Hochberg, Marc C
Cummings, Steven R
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Hillier, Teresa A
Lui, Li-Yung
Kado, Deborah M
LeBlanc, ES
Vesco, Kimberly K
Bauer, Douglas C
Cauley, Jane A
Ensrud, Kristine E
Black, Dennis M
Hochberg, Marc C
Cummings, Steven R
Titel
Height loss in older women: Risk of hip fracture and mortality independent of vertebral fractures
Ist Teil von
Journal of bone and mineral research, 2012-01, Vol.27 (1), p.153-159
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
We examined if height loss in older women predicts risk of hip fractures, other nonspine fractures, and mortality, and whether this risk is independent of both vertebral fractures (VFx) and bone mineral density (BMD) by dual‐energy X‐ray absorptiometry. Among 3124 women age 65 and older in the Study of Osteoporotic Fractures, we assessed the association with measured height change between year 0 (1986–1988) and year 15 (2002–2004) and subsequent risk of radiologically confirmed hip fractures, other nonspine fractures, and mortality assessed via death certificates. Follow‐up occurred every 4 months for fractures and vital status (>95% contacts complete). Cox proportional hazards models assessed risk of hip fracture, nonspine fracture, and mortality over a mean of 5 years after height change was assessed (ie, after final height measurement). After adjustment for VFx, BMD, and other potential covariates, height loss >5 cm was associated with a marked increased risk of hip fracture [hazard ratio (HR) 1.50, 95% confidence interval (CI) 1.06, 2.12], nonspine fracture (HR 1.48; 95% CI 1.20, 1.83), and mortality (1.45; 95% CI 1.21, 1.73). Although primary analyses were a subset of 3124 survivors healthy enough to return for a year 15 height measurement, a sensitivity analysis in the entire cohort (n = 9677) using initial height in earlier adulthood [self‐reported height at age 25 (−40 years) to measured height age >65 years (Year 0)] demonstrated consistent results. Height loss >5 cm (2″) in older women was associated with a nearly 50% increased risk of hip fracture, nonspine fracture, and mortality—independent of incident VFx and BMD. © 2012 American Society for Bone and Mineral Research
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.558
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3622730
Format
–
Schlagworte
Aged
,
AGING
,
Biological and medical sciences
,
Body Height
,
Cohort Studies
,
EPIDEMIOLOGY
,
Female
,
Fundamental and applied biological sciences. Psychology
,
Hip Fractures - etiology
,
Hip Fractures - mortality
,
Hip Fractures - physiopathology
,
Humans
,
OSTEOPOROSIS
,
POPULATION STUDIES
,
Proportional Hazards Models
,
Risk Factors
,
Skeleton and joints
,
Spinal Fractures - etiology
,
Spinal Fractures - mortality
,
Spinal Fractures - physiopathology
,
United States - epidemiology
,
Vertebrates: osteoarticular system, musculoskeletal system
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