Details

Autor(en) / Beteiligte

• COZEN, W
• YU, G
• GAIL, M. H
• RIDAURA, V. K
• NATHWANI, B. N
• HWANG, A. E
• HAMILTON, A. S
• MACK, T. M
• GORDON, J. I
• GOEDERT, J. J

Titel

Fecal microbiota diversity in survivors of adolescent/young adult Hodgkin lymphoma: a study of twins

Ist Teil von

• British journal of cancer, 2013-03, Vol.108 (5), p.1163-1167

Ort / Verlag

Basingstoke: Nature Publishing Group

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their unaffected co-twin controls. Pyrosequencing of fecal bacterial 16S rRNA amplicons yielded 252 943 edited reads that were assigned to species-level operational taxonomic units (OTUs) and standardised for sequencing depth by random sampling. Microbial diversity was compared within vs between twin pairs and by case-control status. The number of unique OTUs was more similar within twin pairs compared with randomly paired participants (P=0.0004). The AYAHL cases had fewer unique OTUs compared with their co-twin controls (338 vs 369, P=0.015); this difference was not significant (169 vs 183, P=0.10) when restricted to abundant OTUs. In this small study, AYAHL survivors appear to have a deficit of rare gut microbes. Further work is needed to determine if reduced microbial diversity is a consequence of the disease, its treatment, or a particularly hygienic environment.