Science (American Association for the Advancement of Science), 2012-03, Vol.335 (6075), p.1496-1499
2012
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Details
- Autor(en) / Beteiligte
- Titel
- MARF1 Regulates Essential Oogenic Processes in Mice
- Ist Teil von
- Science (American Association for the Advancement of Science), 2012-03, Vol.335 (6075), p.1496-1499
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2012
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Development of fertilization-competent oocytes depends on integrated processes controlling meiosis, cytoplasmic development, and maintenance of genomic integrity. We show that meiosis arrest female 1 (MARF1) is required for these processes in mammalian oocytes. Mutations of Marf1 cause female infertility characterized by up-regulation of a cohort of transcripts, increased retrotransposon expression, defective cytoplasmic maturation, and meiotic arrest. Up-regulation of protein phosphatase 2 catalytic subunit (PPP2CB) is key to the meiotic arrest phenotype. Moreover, lap and Linel retrotransposon messenger RNAs are also up-regulated, and, concomitantly, DNA double-strand breaks are elevated in mutant oocytes. Therefore MARF1, by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1214680Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3612990
- Format
- –
- Schlagworte
- Amino Acid Sequence, Animal reproduction, Animals, Base Sequence, Biological and medical sciences, Cell Cycle Proteins - chemistry, Cell Cycle Proteins - genetics, Cell Cycle Proteins - metabolism, Cell differentiation, maturation, development, hematopoiesis, Cell division, Cell physiology, DNA Breaks, Double-Stranded, Embryonic Development, Exons, Female, Females, Fertility, Fundamental and applied biological sciences. Psychology, Gene expression regulation, Genetic mutation, Granulosa cells, Meiosis, Messenger RNA, Mice, Molecular and cellular biology, Molecular Sequence Data, Mutation, Oocytes, Oocytes - physiology, Oogenesis, Phenotype, Phenotypes, Protein Phosphatase 2 - genetics, Protein Phosphatase 2 - metabolism, Protein Structure, Tertiary, Retroelements, Retrotransposons, RNA, Messenger - genetics, RNA, Messenger - metabolism, Rodents, Transcription, Genetic, Transcriptome, Transcripts (Written Records), Up regulation