Details

Autor(en) / Beteiligte

• Narbutt, Joanna
• Olejniczak, Irmina
• Sobolewska-Sztychny, Dorota
• Sysa-Jedrzejowska, Anna
• Słowik-Kwiatkowska, Iwona
• Hawro, Tomasz
• Lesiak, Aleksandra

Titel

Narrow band ultraviolet B irradiations cause alteration in interleukin-31 serum level in psoriatic patients

Ist Teil von

• Archives of Dermatological Research, 2013-04, Vol.305 (3), p.191-195

Ort / Verlag

Berlin/Heidelberg: Springer-Verlag

Erscheinungsjahr

2013

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Scientific communications indicate the disturbed expression of neuropeptides in the skin and serum in psoriasis vulgaris (PsV) patients. Narrow-band ultraviolet radiation (NB-UVB) is one of the systemic therapies of PsV. The aim of the study was to evaluate the influence of NB-UVB therapy on substance P (SP), calcitonin gene-related peptide (CGRP), brain-derived neurotrophic factor (BDNF), corticotropin-releasing factor (CRF) and interleukin-31 (IL-31) serum concentrations in PsV patients. 59 psoriatic patients with mean PASI (psoriasis area and severity index) 14.3 were treated with NB-UVB (20 exposures). The control group consisted of 50 healthy subjects, whose age and sex matched. In all patients, serum concentration of BDNF, CRF, IL-31 substance P and CGRP was analyzed by ELISA before the treatment and in psoriatic group the analysis was also done after 10 and 20 irradiations. In patients there was found a significantly higher concentration of IL-31 (215.3 vs. 748.6 ng/ml; p  < 0.0001), SP (25.7 vs. 67.2 pg/ml; p  < 0.01), CGRP (31.4 vs. 44.15 pg/ml; p  < 0.01) and a lower concentration of CRF (0.89 vs. 0.426 ng/ml; p  < 0.0001) and BDNF (16.39 vs. 14.15 ng/ml; p  = 0.1216) in comparison with the controls. 20 NB-UVB exposures caused a significant decrease in IL-31 level (748.6 vs. 631.7 ng/ml; p  < 0.0001). The NB-UVB therapy had no major effect on neuropeptides serum levels regardless of a number of irradiations. On the basis of our study it can be suggested that IL-31 is involved in pathogenesis of psoriasis and the NB-UVB therapy causes alterations in its level.