Details

Autor(en) / Beteiligte

• Easton, Alexander
• Douchamps, Vincent
• Eacott, Madeline
• Lever, Colin

Titel

A specific role for septohippocampal acetylcholine in memory?

Ist Teil von

• Neuropsychologia, 2012-11, Vol.50 (13), p.3156-3168

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Acetylcholine has long been implicated in memory, including hippocampal-dependent memory, but the specific role for this neurotransmitter is difficult to identify in human neuropsychology. Here, we review the evidence for a mechanistic model of acetylcholine function within the hippocampus and consider its explanatory power for interpreting effects resulting from both pharmacological anticholinergic manipulations and lesions of the cholinergic input to the hippocampus in animals. We argue that these effects indicate that acetylcholine is necessary for some, but not all, hippocampal-dependent processes. We review recent evidence from lesion, pharmacological and electrophysiological studies to support the view that a primary function of septohippocampal acetylcholine is to reduce interference in the learning process by adaptively timing and separating encoding and retrieval processes. We reinterpret cholinergic-lesion based deficits according to this view and propose that acetylcholine reduces the interference elicited by the movement of salient locations between events. ► We review effects of lesion/pharmacological disruption to the cholinergic system. ► We review a model of the role of septohippocampal acetylcholine in memory. ► We review recent behavioural loss-of-function and electrophysiological data. ► We use the model to explain deficits after septohippocampal cholinergic disruption.