Details

Autor(en) / Beteiligte

• Zhou, Kaixin
• Asherson, Philip
• Sham, Pak
• Franke, Barbara
• Anney, Richard J.L.
• Buitelaar, Jan
• Ebstein, Richard
• Gill, Michael
• Brookes, Keeley
• Buschgens, Cathelijne
• Campbell, Desmond
• Chen, Wai
• Christiansen, Hanna
• Fliers, Ellen
• Gabriëls, Isabel
• Johansson, Lena
• Marco, Rafaela
• Mulas, Fernando
• Müller, Ueli
• Mulligan, Aisling
• Neale, Benjamin M.
• Rijsdijk, Fruhling
• Rommelse, Nanda
• Uebel, Henrik
• Psychogiou, Lamprini
• Xu, Xiaohui
• Banaschewski, Tobias
• Sonuga-Barke, Edmund
• Eisenberg, Jacques
• Manor, Iris
• Miranda, Ana
• Oades, Robert D.
• Roeyers, Herbert
• Rothenberger, Aribert
• Sergeant, Joseph
• Steinhausen, Hans-Christoph
• Taylor, Eric
• Thompson, Margaret
• Faraone, Stephen V.

Titel

Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings

Ist Teil von

• Biological psychiatry (1969), 2008-10, Vol.64 (7), p.571-576

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2008

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.