Details

Autor(en) / Beteiligte

• Sturt, Amy S.
• Anglemyer, Andrew
• Berk, David R.
• Maldonado, Yvonne A.

Titel

Temporal Trends in Mucocutaneous Findings Among Human Immunodeficiency Virus 1-Infected Children in a Population-Based Cohort

Ist Teil von

• Pediatric dermatology, 2013-07, Vol.30 (4), p.451-456

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective of the study was to determine the prevalence of pediatric human immunodeficiency virus 1 (HIV‐1) mucocutaneous manifestations in the era of highly active antiretroviral therapy (HAART). We conducted population‐based, prospective, multicenter pediatric HIV‐1 surveillance in 276 children with perinatally acquired HIV‐1 from 1988 to 2009. Centers for Disease Control and Prevention (CDC)‐defined HIV‐1 related mucocutaneous conditions among the 276 children were: category A (n = 152), B (n = 60), and C (n = 1). Nearly half of the category A and B diagnoses (43.4% [66/152] and 35.0% [21/60], respectively) occurred in the first year of life, with 59.2% (90/152) and 61.7% (37/60), respectively, occurring in the first 2 years of life. The most frequent infectious diagnosis was oropharyngeal thrush (n = 117, 42.4%); the most common inflammatory diagnosis was diaper dermatitis (n = 71, 25.7%). There was a temporal decline in the prevalence of A (pre‐HAART cohort, 123; post‐HAART cohort, 29; p < 0.01) and B (pre‐HAART, 55; post‐HAART, 5; p < 0.01) mucocutaneous diagnoses. In children with perinatal HIV‐1, there was a significant decline in CDC category A and B mucocutaneous diagnoses by temporal cohort, consistent with the introduction of antiretroviral medications and HAART. Clinical category A and B mucocutaneous diagnoses were most common in the first 2 years of life, emphasizing the importance of early HIV‐1 testing and HAART initiation.