Details

Autor(en) / Beteiligte

• Maheswaran, Shyamala
• Sequist, Lecia V
• Nagrath, Sunitha
• Ulkus, Lindsey
• Brannigan, Brian
• Collura, Chey V
• Inserra, Elizabeth
• Diederichs, Sven
• Iafrate, A. John
• Bell, Daphne W
• Digumarthy, Subba
• Muzikansky, Alona
• Irimia, Daniel
• Settleman, Jeffrey
• Tompkins, Ronald G
• Lynch, Thomas J
• Toner, Mehmet
• Haber, Daniel A

Titel

Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

Ist Teil von

• The New England journal of medicine, 2008-07, Vol.359 (4), p.366-377

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• This study describes a method for capturing circulating tumor cells in patients with non–small-cell lung cancer with the use of antibody tethered to microposts. The isolated cells were of sufficient quantity and purity to genotype and thus could feasibly be used to guide genotype-specific treatment. This study describes a method for capturing circulating tumor cells in patients with non–small-cell lung cancer with the use of antibody tethered to microposts. Increasing knowledge of molecular abnormalities that drive human cancers offers the promise of therapies targeted at specific genetic lesions. 1 , 2 Genetic abnormalities may define a cancer at diagnosis, but mutations, some of which lead to acquired drug resistance, may emerge during treatment. For many epithelial cancers, minimally invasive biopsies provide insufficient material for molecular analysis at diagnosis, and tumors typically are not sampled repeatedly during treatment to monitor changes in genetic abnormalities. Although tumor cells are known to circulate in the blood of patients with metastatic cancer, 3 their use in monitoring of tumor genotypes has been limited by relatively insensitive . . .