Details

Autor(en) / Beteiligte

• Parks, Brian W.
• Nam, Elizabeth
• Org, Elin
• Kostem, Emrah
• Norheim, Frode
• Hui, Simon T.
• Pan, Calvin
• Civelek, Mete
• Rau, Christoph D.
• Bennett, Brian J.
• Mehrabian, Margarete
• Ursell, Luke K.
• He, Aiqing
• Castellani, Lawrence W.
• Zinker, Bradley
• Kirby, Mark
• Drake, Thomas A.
• Drevon, Christian A.
• Knight, Rob
• Gargalovic, Peter
• Kirchgessner, Todd
• Eskin, Eleazar
• Lusis, Aldons J.

Titel

Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice

Ist Teil von

• Cell metabolism, 2013-01, Vol.17 (1), p.141-152

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2013

Quelle

Elsevier ScienceDirect

Beschreibungen/Notizen

• Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) diet of more than 100 inbred strains of mice. Here we show that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provide evidence for a genetically determined set point for obesity. GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity. [Display omitted] ► Detailed analysis of diet-induced obesity in more than 100 inbred mouse strains ► Identification of 11 genetic loci associated with obesity and dietary responsiveness ► Significant overlap between mouse loci with human GWAS loci for obesity ► Strain-specific shifts in gut microbiota composition in response to dietary intervention