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Cortical stimulation causes long-term changes in H-reflexes and spinal motoneuron GABA receptors
Ist Teil von
Journal of neurophysiology, 2012-11, Vol.108 (10), p.2668-2678
Ort / Verlag
United States: American Physiological Society
Erscheinungsjahr
2012
Quelle
MEDLINE
Beschreibungen/Notizen
The cortex gradually modifies the spinal cord during development, throughout later life, and in response to trauma or disease. The mechanisms of this essential function are not well understood. In this study, weak electrical stimulation of rat sensorimotor cortex increased the soleus H-reflex, increased the numbers and sizes of GABAergic spinal interneurons and GABAergic terminals on soleus motoneurons, and decreased GABA(A) and GABA(B) receptor labeling in these motoneurons. Several months after the stimulation ended the interneuron and terminal increases had disappeared, but the H-reflex increase and the receptor decreases remained. The changes in GABAergic terminals and GABA(B) receptors accurately predicted the changes in H-reflex size. The results reveal a new long-term dimension to cortical-spinal interactions and raise new therapeutic possibilities.