Details

Autor(en) / Beteiligte

• Ling, Qi
• Wang, Kai
• Lu, Di
• Guo, Hai-Jun
• Jiang, Wen-Shi
• He, Xiang-Xiang
• Xu, Xiao
• Zheng, Shu-Sen

Titel

Major influence of renal function on hyperlipidemia after living donor liver transplantation

Ist Teil von

• World journal of gastroenterology : WJG, 2012-12, Vol.18 (47), p.7033-7039

Ort / Verlag

United States: Baishideng Publishing Group Co., Limited

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• AIM：To investigate the impact of renal and graft function on post-transplant hyperlipidemia（PTHL） in living donor liver transplantation（LDLT）.METHODS：A total of 115 adult patients undergoing LDLT from January 2007 to May 2009 at a single center were enrolled.Data were collected and analyzed by the China Liver Transplant Registry retrospectively.PTHL was defined as serum triglycerides ≥ 150 mg/dL or serum cholesterol ≥ 200 mg/dL or the need for pharmacologic treatment at the sixth month after LDLT.Early renal dysfunction（ERD） was defined as serum creatinine ≥ 2 mg/dL and/or the need for renal replacement therapy in the first post-transplant week.RESULTS：In 115 eligible patients,the incidence of PTHL was 24.3%.Recipients with PTHL showed a higher incidence of post-transplant cardiovascular events compared to those without PTHL（17.9% vs 4.6%,P = 0.037）.Serum creatinine showed significant positive correlations with total serum triglycerides,both at posttransplant month 1 and 3（P 0.01）.Patients with ERD had much higher pre-transplant serum creatinine levels（P 0.001） and longer duration of pre-transplant renal insufficiency（P 0.001） than those without ERD.Pretransplant serum creatinine,graft-to-recipient weight ratio,graft volume/standard liver volume ratio,body mass index（BMI） and ERD were identified as risk factors for PTHL by univariate analysis.Furthermore,ERD [odds ratio（OR） = 9.593,P 0.001] and BMI（OR = 6.358,P = 0.002） were identified as independent risk factors for PTHL by multivariate analysis.CONCLUSION：Renal function is closely associated with the development of PTHL in LDLT.Post-transplant renal dysfunction,which mainly results from pre-transplant renal insufficiency,contributes to PTHL.